1. 

   1Even Hotel Rochester – Mayo Clinic Area by IHG

   105 reviews

   Economical and practical, good sanitary conditions, convenient shuttle bus to the clinic.

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   fromUS$107per night

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2. 

   2Hilton Rochester Mayo Clinic Area

   111 reviews

   fromUS$196per night

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3. 

   3Hotel Indigo ROCHESTER – MAYO CLINIC AREA by IHG

   113 reviews

   The staff are friendly, and all the facilities are clean. A more detailed explanation of breakfast would be helpful.

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   fromUS$87per night

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4. 

   4Kahler Grand Hotel

   99 reviews

   fromUS$134per night

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5. 

   5AmericInn by Wyndham Rochester Near Mayo Clinic

   100 reviews

   fromUS$76per night

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6. 

   6Aspen Select

   101 reviews

   fromUS$96per night

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7. 

   7Holiday Inn Express ROCHESTER SOUTH - MAYO AREA by IHG

   109 reviews

   fromUS$93per night

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8. 

   8Courtyard Rochester Mayo Clinic Area/Saint Marys

   99 reviews

   fromUS$129per night

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9. 

   9Quality Inn Near Medical Center

   95 reviews

   fromUS$55per night

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10. 

    10Sleep Inn & Suites West-Near Medical Center

    fromUS$83per night

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11. 

    11Best Western Rochester Hotel Mayo Clinic Area/St. Marys

    fromUS$86per night

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12. 

    12Kahler Inn and Suites

    fromUS$125per night

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13. 

    13Homewood Suites by Hilton Rochester Mayo Clinic Area/ Saint Marys

    fromUS$111per night

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14. 

    14Spark by Hilton Rochester South

    fromUS$96per night

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15. 

    15Broadway Plaza, Trademark Collection by Wyndham

    fromUS$166per night

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Compare all 42 hotels in Rochester

Indicative lowest prices collected from Trip.com on Sep 26, 2026. The live price depends on your dates and is shown on Trip.com.