1. 

   Even Hotel Rochester – Mayo Clinic Area by IHG

   105 reviews

   Economical and practical, good sanitary conditions, convenient shuttle bus to the clinic.

   Guest review on Trip.com

   fromUS$107per night

   See availability
2. 

   Hilton Rochester Mayo Clinic Area

   111 reviews

   fromUS$196per night

   See availability
3. 

   Hotel Indigo ROCHESTER – MAYO CLINIC AREA by IHG

   113 reviews

   The staff are friendly, and all the facilities are clean. A more detailed explanation of breakfast would be helpful.

   Guest review on Trip.com

   fromUS$87per night

   See availability
4. 

   Kahler Grand Hotel

   99 reviews

   fromUS$134per night

   See availability
5. 

   AmericInn by Wyndham Rochester Near Mayo Clinic

   100 reviews

   fromUS$76per night

   See availability
6. 

   Aspen Select

   101 reviews

   fromUS$96per night

   See availability
7. 

   Holiday Inn Express ROCHESTER SOUTH - MAYO AREA by IHG

   109 reviews

   fromUS$93per night

   See availability
8. 

   Courtyard Rochester Mayo Clinic Area/Saint Marys

   99 reviews

   fromUS$129per night

   See availability
9. 

   Quality Inn Near Medical Center

   95 reviews

   fromUS$55per night

   See availability
10. 

    Sleep Inn & Suites West-Near Medical Center

    fromUS$83per night

    See availability
11. 

    Best Western Rochester Hotel Mayo Clinic Area/St. Marys

    fromUS$86per night

    See availability
12. 

    Kahler Inn and Suites

    fromUS$125per night

    See availability
13. 

    Homewood Suites by Hilton Rochester Mayo Clinic Area/ Saint Marys

    fromUS$111per night

    See availability
14. 

    Spark by Hilton Rochester South

    fromUS$96per night

    See availability
15. 

    Broadway Plaza, Trademark Collection by Wyndham

    fromUS$166per night

    See availability
16. 

    Hampton Inn & Suites Rochester-North

    Love this hotel stayed here when our house was getting finished would highly recommend this hotel Great breakfast clean rooms good service

    Guest review on Trip.com

    fromUS$107per night

    See availability
17. 

    TownePlace Suites Rochester Mayo Clinic Area

    fromUS$138per night

    See availability
18. 

    Residence Inn Rochester Mayo Clinic Area South

    fromUS$153per night

    See availability
19. 

    TownePlace Suites Rochester

    fromUS$98per night

    See availability
20. 

    Rochester Marriott Mayo Clinic Area

    fromUS$225per night

    See availability
21. 

    Fairfield Inn & Suites Rochester Mayo Clinic Area/Saint Marys

    fromUS$112per night

    See availability
22. 

    Holiday Inn Express & Suites ROCHESTER – MAYO CLINIC AREA by IHG

    fromUS$96per night

    See availability
23. 

    Hyatt House Rochester/Mayo Clinic

    fromUS$144per night

    See availability

24. Springhill Suites Rochester Mayo Clinic Area Saint Marys

    fromUS$108per night

    See availability

25. Staybridge Suites ROCHESTER - COMMERCE DR NW by IHG

    Booking is completed on Trip.com

    See availability

26. 1742 Uptown // Stylish w/Updates, 3BD, Walk to Mayo, Pet Friendly

    Booking is completed on Trip.com

    See availability

27. Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio

    Booking is completed on Trip.com

    See availability

28. The BEST Stay in Town: See Pictures to Believe

    Booking is completed on Trip.com

    See availability

29. Willow Inn Suites Rochester

    Booking is completed on Trip.com

    See availability

30. The Gwen // Charming 2-bedroom upstairs apartment in quiet duplex

    Booking is completed on Trip.com

    See availability

31. Home Calls the Heart- 10 minutes to Mayo. Split-level home with fenced-in yard.

    Booking is completed on Trip.com

    See availability

32. Warm and cozy property<br>2 miles to Mayo and St. Mary’s. 4 bedrooms, 3 bathrooms.<br>

    Booking is completed on Trip.com

    See availability

33. The Best of Southwest Rochester, MN

    Booking is completed on Trip.com

    See availability

34. Coastal Charm meets Farmhouse living in a cozy single-family. 8 min to Mayo.

    Booking is completed on Trip.com

    See availability

35. Med City Inn & Suites Rochester Mayo Clinic Area

    Booking is completed on Trip.com

    See availability

36. Oasis Luxe Suite—Steps from Mayo Clinic Hospital

    Booking is completed on Trip.com

    See availability

37. Red Juniper House // 4BR, 2.5 Bath, Large Yard, Pet Friendly, 3mi to Mayo Clinic

    Booking is completed on Trip.com

    See availability

38. Main Floor 2 Bedroom, 1 Bath, Easy Walk to Mayo Clinic, Trails, Parks, Shopping

    Booking is completed on Trip.com

    See availability

39. Birch Hill Suites Rochester - Med City

    Booking is completed on Trip.com

    See availability

40. Econo Lodge Mayo Clinic Area

    Booking is completed on Trip.com

    See availability

41. Discounted Charming 2-Bedroom Main-Level Triplex in Rochester

    Booking is completed on Trip.com

    See availability

42. Discounted 5-Star 3 Bedroom Duplex 5 Minutes to Mayo Clinic!

    Booking is completed on Trip.com

    See availability

Indicative lowest prices collected from Trip.com on Sep 26, 2026. The live price depends on your dates and is shown on Trip.com. · Top hotels in Rochester